Cell membranes, Lipid Bilayers, and the Elastica Functional
نویسندگان
چکیده
منابع مشابه
Cell membranes, Lipid Bilayers, and the Elastica Functional
We study an energy functional that arises in a simplified two-dimensional model for lipid bilayer membranes. We demonstrate that this functional, defined on a class of spatial mass densities, favours concentrations on ‘thin structures’. Stretching, fracture and bending of such structures all carry an energy penalty. In this sense we show that the models captures essential features of lipid bila...
متن کاملElectroporation of Planar Lipid Bilayers and Membranes
Strong external electric field can destabilize membranes and induce formation of pores thus increasing membrane permeability. The phenomenon is known as membrane electroporation, sometimes referred to also as dielectric breakdown or electropermeabilization. The structural changes involving rearrangement of the phospholipid bilayer presumably lead to the formation of aqueous pores, which increas...
متن کاملTriglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes
Triglycerides have a limited solubility, around 3%, in phosphatidylcholine lipid bilayers. Using millisecond-scale course grained molecular dynamics simulations, we show that the model lipid bilayer can accommodate a higher concentration of triolein (TO) than earlier anticipated, by sequestering triolein molecules to the bilayer center in the form of a disordered, isotropic, mobile neutral lipi...
متن کاملInteraction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes.
PBP 10, an antibacterial, cell membrane-permeant rhodamine B-conjugated peptide derived from the polyphosphoinositide binding site of gelsolin, interacts selectively with both lipopolysaccharides (LPS) and lipoteichoic acid (LTA), the distinct components of gram-negative and gram-positive bacteria, respectively. Isolated LPS and LTA decrease the antimicrobial activities of PBP 10, as well as ot...
متن کاملA generic model for lipid monolayers, bilayers, and membranes
We describe a simple coarse-grained model which is suited to study lipid layers and their phase transitions. Lipids are modeled by short semiflexible chains of beads with a solvophilic head and a solvophobic tail component. They are forced to self-assemble into bilayers by a computationally cheap ‘phantom solvent’ environment. The model reproduces the most important phases and phase transitions...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PAMM
سال: 2006
ISSN: 1617-7061,1617-7061
DOI: 10.1002/pamm.200610004